In 2014, Takayama et al. [38] initial attempted to elucidate the in vitro metabolism of ADB-FUBINACA by analysing the metabolites produced by the action with the cytochrome P450 enzymes following 1 h of incubation with human liver microsomes. Working with UPLC/ESI-MS/MS, the authors recognized a single metabolite, ensuing from oxidation of the NFin